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bcl
Targeting Leukemic Stem Cells by BCL-2 Inhibition
By admin at 2006-11-18 04:40
 

HOUSTON, Nov. 17 /PRNewswire/ -- Researchers at The University of Texas M. D. Anderson Cancer Center have found, in laboratory studies, that the experimental drug ABT-737 which has shown promise in some cancers, can destroy acute myeloid leukemiaterm (AML) blastterm, progenitor and even stem cells that are often resistant to standard chemotherapyterm treatment.

The drug was powerful in its own right, the researchers say, but they found that some AML cells were themselves resistant to ABT-737, so they added another drug that knocked out this secondary resistance. Together, these agents may provide a powerful therapy against AML, and could form the basis of a new way to treat the cancer, say the scientists, whose study was published in the November 14 issue of the journal, Cancer Cell.

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