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arsenic
Arsenic-based therapy shown to help eradicate leukemia-initiating cells
By Dross at 2008-05-12 21:45
 

BOSTON -- In both leukemiaterm and solid tumors, there exists among the multitude of warrior cancer cells a small subgroup that work undercover, patiently lying in wait to launch their attacks. Known as either cancer initiating cells (CICs) or leukemia initiating cells (LICs), these stealth populations are impervious to conventional chemotherapyterm and undaunted by targeted cancer therapies. When a leukemia patient relapses following a period of remission, it is the LICs that bear responsibility for the disease’s reemergence.

The secret to the survival abilities of these cells has been unclear. But in a paradoxical discovery, a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has found that a tumor suppressor protein known as PML appears to be the factor that enables LICs to maintain their quiescence – the inert state that protects them from being destroyed by cancer therapies – and suggests that inhibition of PML is a promising target for new therapeutics.

read more | 2991 reads

Nanoparticle-arsenic combination makes for more potent anticancer agent
By admin at 2006-11-14 07:16
 
Thomas O’Halloran, Ph.D., and colleagues at Northwestern University’s Nanomaterials for Cancer Diagnostics and Therapeutics Center for Cancer Nanotechnology Excellence (CCNE) report on a new method of incorporating arsenic trioxide into lipid particles in order to aid in entrance to tumor cells. What makes their method unique is that by prefilling the lipid spheres with metals, the arsenic trioxide binds tighter and releases acetic acid, which pushes the equilibrium or arsenic towards entering the cell, sort of a positive feedback mechanism.

[url]http://www.nanowerk.com/news/newsid=1017.php[/url]
read more | 2101 reads

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