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By HCat at 2007-01-16 12:35
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Colorectal Cancer Basics
Hereditary CRC
Colorectal cancer (CRC) can be divided into two basic types, hereditary or sporadic.
   Hereditary CRC are germlineterm (passed to offspring) mutations (a damaging change in DNA) with two well described forms. These hereditary mutations are thought to reduce the time it takes for the cells to turn cancerous. Mutations can be thought of in terms of “hitsâ€. One hit is one mutation. It is thought that a normal cell needs 3 to 6 hits to become cancerous. With an inherited mutation, there is one fewer hit needed to reach the correct number to transform the cell to cancer. One odd aspect to CRC is that there is a relatively well defined set of events for the progression from adenomaterm to carcinomaterm.
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By HCat at 2007-01-05 07:30
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   A medium size clinical trial has shown that taking a daily aspirin (81mg) can substantially reduce the occurrence of advanced colorectal adenomas as well as a less but still significant reduction in non-advanced adenomas. One peculiar thing about the trial is that at a higher dose (325mg) of aspirin the benefit is not there. Also, it is known that this regime requires up to 10 years of daily aspirin to see an effect, and even then, once the aspirin stops there is no lingering protective effect. This 10 year treatment requirement may be a reason why this trial did not find a protection in using the higher dose since this particular trial went for 3 years. The following review provides excellent insight into not only colorectal cancer benefits but a general cancer chemopreventive (chemical protection) effect of aspirin.
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