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apl.pml
Germany - Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic
By Dross at 2010-11-05 04:30
 

Acute promyelocytic leukemiaterm is defined by a characteristic morphology (AML FAB M3/M3v), by the specific translocation t(15;17) and its molecular correlates (PML/RARa and RARa/PML). Thereby it can be separated from all other forms of acute leukemia.

read more | 1773 reads

Translocation Kidney Cancer after Chemotherapy in Childhood
By Dross at 2007-04-22 22:28
 

This article out of Johns Hopkins reviewed the risk of renal cell carcinomaterm occurring as a secondary malignancy after chemotherapyterm in childhood. It is known that children who survive cancer are at the risk of developing another malignancy 20 times more likely than the general population. This study described the clinical, pathologic, cytogenetic, and molecular data on six translocation renal cell carcinomas that arose in five patients who had received chemotherapy.

At the time of diagnosis, the children were between the ages of 6-22 years. Histologically, the tumor showed typical features that are described for translocation renal cell carcinomas. At the molecular level, three of the tumors contained the ASPL-TFE3 fusion; two contained Alpha-TFEB and one contained PRCC-TFE3. The time span between chemotherapy and the diagnosis of these renal cell carcinomas ranged from 4-13 years. The indications varied and including acute promyelocytic leukemiaterm, acute myeloid leukemia, bilateral Wilms' tumor, systemic lupus erythematosus, and a conditioning regimen of bone marrow transplantation secondary to Hurler's syndrome. This latter patient also received radiation.

read more | 3801 reads

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