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Tarceva
Antivascular activity of lapatinib and bevacizumab in primary microcluster cultures of breast cancer and other human neoplasms
By gdpawel at 2008-09-12 04:09
 

Antivascular activity of lapatinib and bevacizumabtermterm in primary microcluster cultures of breast cancer and other human neoplasms

Sub-category: New Systemic Agents - New drugs and targets (includes anti-angiogenics) - Other

Category: Treatment

Meeting: 2008 Breast Cancer Symposium

Abstract No: 166

Author(s): L. Weisenthal, D. J. Lee, N. Patel

Abstract:

Background:

The following tyrosine kinase inhibitors (TKI) have been shown to have antivascular (AV) activity: sunitinibterm (Su), sorafenibterm (So), gefitinib (G), erlotinib (E), and imatinib (I). To date, AV activity has not been reported for lapatinib (LAP).

read more | 1 comment | 4272 reads

PF-3512676 (CPG 7909) Non-Small-Cell-Lung Immuno-modulatory Treatment Development History
By HCat at 2007-03-17 07:11
 

    Coley Phamaceutical Group has developed oligonucleotides which contain CpG motifs (the nucleotides cytosine and guanine in repetition) that help immune responses. The oligonucleotides illicit an immune response by affecting toll-like receptor (TLR) function, with the main one being TLR9. Here is a link to a basic picture of TLR function in the immune response from the company website. The CpG motifs in bacterial DNA have been shown years ago to illicit an immune response. Here is a link to an abstract of a paper on induction of an immune response by CpG motifs from bacterial DNA.

read more | 8987 reads

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