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antibody
Antibody retards growth and induces death in liver cancer cells
By Dross at 2007-07-11 22:52
 

PITTBURGH, July 11 – Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer in the July issue of Molecular Cancer Therapeutics. Using a newly available monoclonal antibodyterm, they demonstrated significant reductions in tumor cell proliferation and survival in human and mouse hepatocellular cancer (HCC) cell lines. According to the researchers, this finding has significant implications not only for the treatment of liver cancer but for a number of different types of cancer.

Most cases of HCC are secondary to either a viral hepatitis infection or cirrhosis of the liver. Despite recent advances, it remains a disease of grim prognosis due to the poorly understood mechanism of how the disease originates and spreads. Most patients live only a short time after diagnosis.

read more | 4035 reads

Antibody signal may redirect inflammation to fuel cancer
By Dross at 2007-02-19 21:19
 

As evidence mounts that the body's normally protective inflammation response can drive some precancerous tissues to become fully malignant, UCSF scientists report discovering an apparent trigger to this potentially deadly process. Typically, the "innate" immune system's Pac-Man-like white blood cells, or leukocytes, engulf and destroy invading microbes when receptors on their surface receive a signal from serum in the blood -- often an antibodyterm produced by a B cell in the separately evolved "acquired" immune system.

read more | 2016 reads

Patented Technology Could Improve Efficacy of Monoclonal Antibodies
By HCat at 2007-02-06 10:34
 

    BioWa, Inc has a patented technology platform called Potelligent which modifies monoclonal antibodies so that they have enhanced binding to increase Antibodyterm-dependent cellular cytotoxicity (ADCC). ADCC is the mechanism by which some antibodies can kill cancer cells. Once an antibody binds to a cell, Natural Killer (NK) cells and Monocytes in the immune system attack the bound cell, ultimately killing it.

    UCB biopharmaceutical company has been has been allowed to use Potelligent in order to develop new antibodies toward novel targets. The enhanced ADCC could help bring new antibodies to market that have greater efficacy while possibly lowering production costs of the treatment. Erbituxterm and Herceptin are antibodies whose efficacy is dependent on ADCC.

read more | 3340 reads

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