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colorectal
Dartmouth Study Uses the Patient's Tumor to Form Vaccine
By Dross at 2010-11-29 22:45
 

A new process for creating a personalized vaccine may become a crucial tool in helping patients with colorectal cancer develop an immune response against their own tumors. This dendritic cell (DC) vaccine, developed at Dartmouth and described in a research paper published this week in the journal Clinical Cancer Research, was used after surgical resection of metastaticterm tumors to try to prevent the growth of additional metastases.

read more | 2 comments | 2223 reads

Screening tool can detect colorectal cancer from a small blood sample
By Dross at 2010-09-30 04:50
 

DENVER — A new microRNA (miRNA) screening assay detected the majority of early-stage colorectal cancers with good specificity and sensitivity.

"Our test has the potential to be safe, cheap, robust, accurate and of little or no inconvenience to the individual, and could, therefore, easily be integrated into national screening programs as part of an annual checkup," said Søren Jensby Nielsen, Ph.D., scientific manager, Diagnostic Product Development, Exiqon A/S.

read more | 3 comments | 1431 reads

Surgical treatment provides new option for some colorectal cancer patients
By Dross at 2008-10-01 02:27
 

WINSTON-SALEM, N.C. – Research out of Wake Forest University School of Medicine suggests that a surgical technique not traditionally used in advanced abdominal cancer may be a viable treatment option for some patients previously thought to be untreatable, offering the real possibility of extending survival for those patients.

The study, available online this month and scheduled to be published in an upcoming issue of Annals of Surgical Oncology, is the first to compare the success of techniques used to remove liver cancers to the effectiveness of those same techniques in removing cancers from the abdominal wall.

read more | 1159 reads

Obesity raises risks of serious digestive health concerns
By Dross at 2008-08-20 02:39
 

Incidence of GERD, colorectal cancer increase with body mass

Bethesda, MD, August 19, 2008 – The prevalence of obesity and overweight in the United States coupled by the increased risk of gastrointestinal diseases related to obesity raises serious implications for the health of Americans. Several scientific studies in the August issue of The American Journal of Gastroenterology examine the association between obesity and the risk of colorectal cancer and gastroesophageal reflux disease, or GERD.

Dr. Frank K. Friedenberg and colleagues from Temple University School of Medicine in Philadelphia provide an extensive overview of scientific research on the epidemiologic and pathophysiologic associations between obesity and GERD.

read more | 1183 reads

Colon Cancer’s Potential for Metastasis Determined Early
By Dross at 2008-03-07 00:00
 

Some colon cancers are destined to spread to the liver and other parts of the body, whereas others are successfully treated by surgical removal of the tumor. Now, Howard Hughes Medical Institute investigators have found that the ability of a colon tumor to metastasize arises early in its development.

Those colon cancers that spread carry the ability to metastasize from the time they become cancerous, the researchers found. They don't need to acquire any new genetic mutations to become metastaticterm. The research also suggests that once a colon carcinomaterm develops, if it is going to spread outside the colon, it will do so in less than two years.

read more | 1 comment | 2256 reads

It's Time to Reassess the Value, Safety of Multivitamin Use, Says Harvard Men's Health Watch
By Dross at 2008-02-28 02:23
 

BOSTON, Feb. 27 -- Although physician-scientists and supplement manufacturers are often at odds, they don't spend much time sparring over multivitamins. In fact, half the physicians on the Harvard Men's Health Watch advisory board report taking a multivitamin themselves. In recent years, Harvard Men's Health Watch has also endorsed these popular supplements, reasoning that even if they don't help, they won't hurt. However, the March 2008 issue of the newsletter states that a reappraisal of that advice is in order.

Harvard Men's Health Watch notes that some recent studies have linked multivitamin use to prostate cancer. More convincingly, studies have linked high intakes of folic acid to colon polyps, the precursors of colorectal cancer. Researchers speculate that high intakes of folic acid, which was first added to grain products in the 1990s, may have contributed to an increase in colorectal cancers in the mid-1990s.

read more | 3 comments | 1681 reads

Picoplatin Safety Data in Colorectal Cancer
By Dross at 2008-01-28 02:33
 

Poniard Pharmaceuticals, Inc. (NASDAQ:PARD) , a biopharmaceutical company focused on oncology, today announced that it has presented safety data from a Phase 1 dose-escalation study of picoplatin, the Company's lead product candidate, at the 2008 Gastrointestinal Cancers Symposium, a meeting of the American Society of Clinical Oncology (ASCO) which is being held in Orlando, Fla.

The poster presentation included safety data from a Phase 1 study of picoplatin in combination with 5-fluorouraciltermtermtermterm (5FU) and leucovorintermterm (LV) as a first-line treatment for metastaticterm colorectal cancer (mCRC). The Phase 1 study seeks to establish the maximum tolerated dose of picoplatin and provide information on the safety of picoplatin when combined with 5FU and LV for the treatment of colorectal cancer. Promising safety data observed from the study to date formed the basis for further development of picoplatin in our ongoing Phase 2 trial in mCRC.

read more | 2191 reads

Regular, long-term aspirin use reduces risk of colorectal cancer
By Dross at 2008-01-22 23:34
 

Bethesda, MD (Jan. 18, 2008) – The use of regular, long-term aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk associated with colorectal cancer, according to a study published in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. However, the use of aspirin for chemoprevention of colorectal cancer may require using the drug at doses that are higher than recommended over a long period of time, which may cause serious side effectsterm including gastrointestinal bleeding.

“While the results of our study show that aspirin should not currently be recommended for the chemoprevention of colorectal cancer in a healthy population, there is a need for further studies to help identify for which patients the potential benefits outweigh the risks,” according to Andrew T. Chan, MD, MPH, Massachusetts General Hospital and lead author of the study. “We also need to improve our understanding of how aspirin works to prevent and inhibit the formation of colorectal cancer.”

read more | 1333 reads

Nektar Commences Phase 2 Clinical Development Program for NKTR-102 (PEG-Irinotecan) in Colorectal Cancer
By Dross at 2008-01-08 22:56
 

SAN CARLOS, Calif., Jan. 8 /PRNewswire-FirstCall/ -- Nektar Therapeutics (NASDAQ:NKTR) today announced the start of its Phase 2 clinical development program to evaluate NKTR-102 (PEG-irinotecantermterm) as a potential treatment for colorectal cancer. NKTR-102 is Nektar's lead oncolytic candidate using the company's innovative small molecule PEGylation technology platform.

"The start of the Phase 2 program for NKTR-102 in colorectal cancer is a major achievement for Nektar," said Howard W. Robin, Nektar President and Chief Executive Officer. "Our Phase 2 program has the potential to demonstrate Nektar's ability to generate innovative and important PEGylated small molecule therapeutics. Based on our positive Phase 1 study findings, we also plan to initiate Phase 2 studies this year to evaluate NKTR-102 in multiple solid tumor settings."

read more | 1920 reads

Curry-derived molecules might be too spicy for colorectal cancers
By Dross at 2007-11-05 20:46
 

SINGAPORE -- Curcumin, the yellowish component of turmeric that gives curry its flavor, has long been noted for its potential anti-cancer properties. Researchers from Tohoku University in Sendai, Japan, report on an apparent improvement upon nature: two molecular analogues of curcumin that demonstrate even greater tumor suppressive properties. The team presented their findings from the first test of these molecules in a mouse model of colorectal cancer today at the American Association for Cancer Research Centennial Conference on Translational Cancer Medicine.

According to Tohoku University researcher Hiroyuki Shibata, M.D., curcumin is one of the most widely studied plant-based chemicals with anti-cancer properties. Research has associated curcumin with several distinct actions, including the suppression of genes that promote cell growth (for example, the destruction of the pro-cancerous protein â catenin), and induction of programmed cell death (apoptosis) in colorectal cancer.

read more | 1387 reads

Increased glucose level is a strong risk factor for colorectal cancer
By Dross at 2007-11-05 05:16
 

Bethesda, MD (November 1, 2007) – Diabetes is a very common illness that affects more than 20 million people in the U.S. and it is estimated an additional 54 million Americans have pre-diabetes, a condition that occurs when a person's blood glucose levels are higher than normal but not high enough for a diagnosis of type 2 diabetes. Therefore, it is important to determine whether glucose and insulin levels are associated with a higher risk of colon polyps, the precursor lesions to colon cancer. According to the results of a study published in Gastroenterology, patients with high levels of insulin and glucose are at increased risk of developing recurrent colorectal adenomas, or tumors, with elevated glucose providing the strongest risk factor for recurrence of these lesions.

read more | 2565 reads

18F-DG PET/CT can highly increase the detection of colorectal cancer
By Dross at 2007-10-11 07:50
 

Combined positron emission tomography and computed tomography (PET/CT) is currently widely used in the clinical diagnosis of cancer to provide functional and morphological imaging. The value of PET/CT in detection of the recurrence and metastasistermterm of colorectal cancer (CRC) was recently confirmed in an article appearing in the October 7 issue of the World Journal of Gastroenterology.

The research performed at the Department of Medical Oncology, Jinling Hospital, China. Dr. Chen and his colleagues observed a total of 68 postoperative CRC patients, 48 male and 20 female, who were examined in the Jinling Hospital PET/CT Center between August 2004 and August 2006. After PET/CT imaging, recurrence and/or metastasis were confirmed in 82.4% (56/68) of the patients, with 91.7% (22/24) cases with elevated serum CEA levels. PET/CT detected more lesions than CT or ultrasonography alone in 30.4 % (17/56) of the cases of recurrence and/or metastasis.

read more | 1702 reads

A gene for metastasis
By Dross at 2007-08-28 20:26
 

Colorectal cancer is one of the most prevalent cancers in the Western world. The tumor starts off as a polyp but then turns into an invasive and violent cancer, which often spreads to the liver. In an article recently published in the journal Cancer Research, Prof. Avri Ben-Ze’ev and Dr. Nancy Gavert of the Weizmann Institute’s Molecular Cell Biology Department reveal mechanisms that help this cancer metastasize.

In a majority of cases, colorectal cancer is initiated by changes in a key protein – beta-catenin. One of the roles of this protein is to enter the cell nucleus and activate gene expression. But in colorectal and other cancers, beta-catenin over-accumulates in the cell and inappropriately activates genes, leading to cancer.

read more | 3 comments | 1926 reads

Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
By Dross at 2007-08-04 00:51
 

PHILADELPHIA – A therapeutic cancer vaccine has shown effectiveness when given alongside chemotherapyterm to patients with metastaticterm colorectal cancer in a phase II trial, according to researchers at Oxford BioMedica (UK) Ltd. The study found that six of the 17 metastatic colorectal cancer patients in the study showed tumor shrinkage, classified as complete or partial responses following independent expert review.

The study, reported in the August 1 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, was designed to demonstrate the safety and immunogenicity of the vaccine, called modified vaccinia Ankara-encoding 5T4 (TroVax®), when used alongside standard chemotherapy. The research was funded by Oxford BioMedica which is developing the vaccine in partnership with Sanofi-Aventis.

read more | 2118 reads

Researchers probe risks, benefits of folic acid fortification
By Dross at 2007-07-10 12:15
 

BOSTON — Since the institution of nationwide folic acid fortification of enriched grains in the mid 1990s, the number of infants born in the United States and Canada with neural tube defects has declined by 20 percent to 50 percent. Concurrent with the institution of fortification, however, the rate at which new cases of colorectal cancer were diagnosed in men and women increased, report researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University. Joel Mason, MD, director of the USDA HNRCA’s Vitamins and Carcinogenesis Laboratory, and colleagues analyze the temporal association between folic acid fortification and the rise in colorectal cancer rates, and present their resulting hypothesis in an article in the July issue of Cancer Epidemiology Biomarkers & Prevention.

read more | 2 comments | 1381 reads

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