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oligonucleotide
PF-3512676 (CPG 7909) Non-Small-Cell-Lung Immuno-modulatory Treatment Development History
By HCat at 2007-03-17 07:11
 

    Coley Phamaceutical Group has developed oligonucleotides which contain CpG motifs (the nucleotides cytosine and guanine in repetition) that help immune responses. The oligonucleotides illicit an immune response by affecting toll-like receptor (TLR) function, with the main one being TLR9. Here is a link to a basic picture of TLR function in the immune response from the company website. The CpG motifs in bacterial DNA have been shown years ago to illicit an immune response. Here is a link to an abstract of a paper on induction of an immune response by CpG motifs from bacterial DNA.

read more | 8174 reads

Geron’s GRN163L Headed to Phase I Clinical Trials in Lung Cancer Patients
By HCat at 2007-02-17 08:26
 

    Geron Corporation has published preclinical data on GRN163L indicating anti-tumor and anti-metastaticterm activity. Released in this month’s Cancer Research, the new study ascribes the anti-metastatic effects of GRN163L to its unique structure, and not it known human telomerase RNA (hTR) inhibition. By successive shortening of this oligonucleotide (specifically N3’ to P5’ Thio-Phosphoramidate), the authors show that cell adhesion in a lung cell line is reduced due the structural aspects of GRN163L and not is inhibitory effect on hTR. Also, in mice models of metastatic lung cancer, the researchers show a reduced tumor burden in mice treated with GRN163L upon inoculation with the cancer cells.

read more | 3519 reads

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