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hTR
Geron’s GRN163L Headed to Phase I Clinical Trials in Lung Cancer Patients
By HCat at 2007-02-17 08:26
 

    Geron Corporation has published preclinical data on GRN163L indicating anti-tumor and anti-metastaticterm activity. Released in this month’s Cancer Research, the new study ascribes the anti-metastatic effects of GRN163L to its unique structure, and not it known human telomerase RNA (hTR) inhibition. By successive shortening of this oligonucleotide (specifically N3’ to P5’ Thio-Phosphoramidate), the authors show that cell adhesion in a lung cell line is reduced due the structural aspects of GRN163L and not is inhibitory effect on hTR. Also, in mice models of metastatic lung cancer, the researchers show a reduced tumor burden in mice treated with GRN163L upon inoculation with the cancer cells.

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