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bevacizumab
Bevacizumab found to improve survival for patients with advanced breast cancer
By Dross at 2007-12-27 23:46
 

Inhibiting the growth of blood vessels that supply tumors slows the progression of metastaticterm breast cancer according to results of a large clinical trial of Avastinterm, an anti-angiogenic therapy. The study, published in the December 27th issue of the New England Journal of Medicine, found that Avastin in combination with chemotherapyterm significantly prolongs progression-free survival for women with breast cancer compared to chemotherapy alone.

Rush University Medical Center participated in the clinical trial which was sponsored by the National Cancer Institute and conducted by a network of researchers led by the Eastern Cooperative Oncology Group (ECOG).

read more | 4 comments | 1824 reads

St. Jude study shows temporary improvement of tumor blood flow can improve chemotherapy
By Dross at 2007-07-12 19:17
 

A treatment for neuroblastoma that lands a one-two punch works best when the second punch is timed to take maximum advantage of the first one, according to results of studies at St. Jude Children’s Research Hospital. Neuroblastoma is a pediatric solid tumor that arises from cells in the peripheral nervous system.

The finding holds promise for improving neuroblastoma treatment by using the drug bevacizumabtermterm to block VEGFterm, a protein that stimulates blood vessel growth in tumors and then following with the chemotherapyterm drug topotecan, which depends on blood vessels to penetrate the tumor and kill the cancer cells. A report on this work appears in the current issue of “Clinical Cancer Research.”

read more | 1305 reads

Cancer drug can extend survival in patients with deadly brain tumors
By Dross at 2007-02-20 23:56
 

DURHAM, N.C. -- Avastinterm, a relatively new type of drug that shrinks cancerous tumors by cutting off their blood supply, can slow the growth of the most common and deadly form of brain cancer, a pilot study conducted at Duke University Medical Center has found. The study marks the first time that Avastin has been tested against brain tumors, the researchers said. The drug, whose chemical name is bevacizumabtermterm, currently is used to treat lung and colorectal cancers. The researchers tested the effectiveness of Avastin in conjunction with a standard chemotherapyterm agent in patients with recurrent cancerous brain tumors called gliomas. They found that the two drugs together halted tumor growth up to twice as long as comparative therapies.

read more | 2827 reads

New England Journal of Medicine Avastin in Lung Cancer
By admin at 2006-12-19 03:00
 

New England Journal of Medicine Publishes Data from Pivotal Study of Avastinterm Plus Chemotherapyterm in Most Common Type of Lung Cancer

 

 Genentech, Inc. (NYSE-DNA) announced today the publication of data from a pivotal Phase III clinical trial in the New England Journal of Medicine showing that Avastin(R) (bevacizumabtermterm) in combination with paclitaxel and carboplatin chemotherapy significantly improved overall survival in patients with unresectable, locally advanced, recurrent or metastaticterm non-squamous, non- small cell lung cancer (NSCLC), the most common type of lung cancer.

read more | 1 comment | 2360 reads

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