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stem cell transplant
Elasticity found to stretch stem cell growth to higher levels
By Dross at 2010-10-04 21:03

One of the major challenges in stem cell transplants is how to obtain sufficient numbers of these remarkably rare cells to put into patients. To help overcome this issue, research from the Centenary Institute, Royal Prince Alfred Hospital and the University of Sydney has found a way to increase the number of blood-forming stem cells when growing them outside of the body.

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Lung Function Predicts Mortality After Stem Cell Transplant
By Dross at 2007-12-29 00:26

Pulmonary function tests are often performed before hematopoietic stem cell transplantation to screen for underlying respiratory problems. Recent research has suggested that pretransplant pulmonary function tests—particularly a measurement combining FEV1 and the diffusing capacity of carbon dioxide (DLCO)—can predict posttransplant respiratory failure and mortality.1

Jason Chien, MD, and colleagues retrospectively studied the pretransplant pulmonary function and arterial blood gasses of 2,852 cancer patients who received allogeneic stem cell transplants during a 12-year period. FEV1, FVC, total lung capacity, DLCO, and alveolar-arterial oxygen tension difference (PaO2) were measured. Patients in the nonmyeloablative group received 2Gy total body irradiation. Those in the myeloablative group received either total-body-irradiation-based or non-total-body-irradiation-based regimens. According to Dr. Chien, an Assistant Professor of Pulmonary and Critical Care Medicine at the Fred Hutchinson Cancer Center, “Assessment of pretransplant pulmonary function tests is very important, given their relationship with mortality risk. We would like to see every transplant center in the world screen their patients with pretransplant pulmonary function tests.”

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For women, Pathenogenesis is now a reality
By Dross at 2007-12-22 22:10

New Rochelle, NY, December 19, 2007—In a groundbreaking experiment published in Cloning & Stem Cells, scientists from International Stem Cell (ISC) Corp. derived four unique embryonic stem cell lines that open the door for the creation of therapeutic cells that will not provoke an immune reaction in large segments of the population. The stem cell lines are “HLA-homozygous,” meaning that they have only the genetic profile of the mother, but duplicated. Every egg from a woman has one copy of the information needed to raise a woman. Humans need two copies, and the second is usually provided by the father, including either an X or a Y. A group of researchers has simply copied the half that already existed in the egg, and created a new cell with the potential to grow into bllod cells, nerve, or any other needed cell type. This is different to cloning, which would be an exact replica of the mother. The lines could serve to create a stem cell bank as a renewable source of transplantable cells for use in cell therapy to replace damaged tissues or to treat genetic and degenerative diseases. 

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High-dose chemo and stem cell transplant shows little or no survival benefit for breast cancer
By Dross at 2007-12-14 00:24

High-dose chemotherapyterm and autologous stem cell transplantation, the controversial, arduous, yet once-popular combination treatment that fell out of favor as a therapy for breast cancer, has proven not to be beneficial as an adjuvant therapyterm for women with node-positive disease, according to an expansive analysis conducted by researchers at The University of Texas M. D. Anderson Cancer Center.

In a review of 15 randomized high-dose chemotherapy studies conducted around the world between 1988 and 2002, the investigators from M. D. Anderson, in collaboration with the European Blood and Marrow Transplant Group, report that while there was a slight benefit on relapse-free survival, there was no benefit to overall survival. Donald Berry, Ph.D., professor and head of the Division of Quantitative Sciences, presented the findings today at the 30th annual San Antonio Breast Cancer Symposium.

read more | 2 comments | 1286 reads

MGH researchers confirm that bone marrow restores fertility in female mice
By Dross at 2007-08-01 08:24

A new study from Massachusetts General Hospital (MGH) researchers confirms that female mice that receive bone marrow transplantation after fertility-destroying chemotherapyterm can go on to have successful pregnancies throughout their normal reproductive life. The report in the August 1 Journal of Clinical Oncology verifies that donor marrow can restore fertility in female mice through an as-yet unidentified mechanism. While donor-derived egg cells or oocytes were observed in the ovaries of marrow recipients, all pups born were from the recipients’ own eggs.

“Consistent with our past work, cells derived from the donor bone marrow are getting into the ovaries and developing into immature oocytes,” says Jonathan Tilly, PhD, director of the Vincent Center for Reproductive Biology ( at MGH, the study’s senior author. “Although these oocytes derived from marrow cells don’t appear competent, at least thus far, to make fertilizable eggs, marrow does contribute something that allows a resumption of fertility in female mice sterilized by chemotherapy.”

read more | 1812 reads

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