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Molecular Biology
Simply finding a mutation
By gdpawel at 2013-01-07 22:27
 

The idea of simply finding a mutation and then pick an appropriately targeted drug seems like a nice idea. However, not every key that looks like it will fit a lock will actually turn it. The same is likely to be the case with targeted drugs. There are numerous common mutations in various tumor types, but they don't know that all those mutations are going to turn out to be relevant, as many of them are essentially bystanders.

read more | 2 comments | 2112 reads

Molecular Biology vs Cellular Biology
By gdpawel at 2012-09-27 09:52

There is a growing litany of observations that call into question molecular biologist's preternatural fixation on genomic analyses. Human biology is not simple and malignantly transformed cells more complex still. Investigators who insist upon using genomic platforms to force disorderly cells into artificially ordered sub-categories, have once again been forced to admit that these oversimplifications fail to provide the needed insights for the advancement of cancer therapeutics.

read more | 8 comments | 377 reads

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