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chromosome deletion
Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
By Dross at 2007-08-03 22:49
 

In the past ten years, researchers in genome stability have observed that many kinds of cancer are associated with areas where human chromosomes break. They have hypothesized – but never proven – that slow or altered replication led to the chromosomes breaking.

In a Tufts University study published in the Aug. 3 journal "Molecular Cell," two molecular biologists have used yeast artificial chromosomes to prove the hypothesis. The Tufts researchers have found a highly flexible DNA sequence that increases fragility and stalls replication, which then causes the chromosome to break.

read more | 1 comment | 1438 reads

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