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New Discoveries in Cancer and Heart Disease
By gdpawel at 2014-07-02 03:55


Larry M. Weisenthal, M.D., Ph.D.


MCED: A newly-discovered mechanism of endothelial cell death


read more | 5 comments | 17059 reads

Randomized Clinical Trial Paradigm
By gdpawel at 2012-05-13 00:19

The mindset of cancer medicine is to think it's great science to identify the best treatment to give to the average patient is through prospective, randomized trials. We have produced an entire generation of investigators in clinical oncology who believe that the only valid form of clinical research is to perfrom well-designed, prospective randomized trials in which patients are randomized to receive one empiric drug combination versus another empiric drug combination. Do cancer cells like Coke or Pepsi?

read more | 27 comments | 7504 reads

For Personalizing Cancer Therapy, Metabolic Profiles Are Essential
By gdpawel at 2012-02-09 13:12

One way to tackle a tumor is to take aim at the metabolic reactions that fuel their growth. But a report in the February Cell Metabolism, a Cell Press Publication, shows that one metabolism-targeted cancer therapy will not fit all. That means that metabolic profiling will be essential for defining each cancer and choosing the best treatment accordingly, researchers say.

read more | 4 comments | 13240 reads

Regular exercise reduces large number of health risks including dementia and some cancers
By Dross at 2010-11-16 04:05

People who take regular exercise could reduce their risk of developing around two dozen physical and mental health conditions - including some cancers and dementia - and slow down how quickly their body deteriorates as they age.

An extensive research review, published in the December issue of IJCP, the International Journal of Clinical Practice, says that apart from not smoking, being physically active is the most powerful lifestyle choice any individual can make to improve their health.

read more | 1499 reads

Weakened RNA Interference Reduces Survival In Ovarian Cancer
By gdpawel at 2009-01-09 04:44

Levels of two proteins in a woman's ovarian cancer are strongly associated with her likelihood of survival, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the Dec. 18 issue of the New England Journal of Medicine.

The study shows that women with high levels of Dicer and Drosha, two proteins that are vital to a cell's gene-silencing machinery, had a median survival of 11 years. For those with low levels of either or both proteins, median survival was 2.66 years.

read more | 1848 reads

Tests Could Predict Benefit From Cancer Drugs
By gdpawel at 2008-11-02 08:57
Markers in blood or tumor tissue may help those fighting colon, lung or pancreatic malignancies.

What if a blood test or biopsy could predict if a cancer therapy will help cure you, or only make you feel worse?

Tests like these, based on genes, proteins or other "molecular markers" may someday do just that for people battling colon, lung and pancreatic tumors, scientists reported at a news conference.

"The ultimate goal is to bring personalized medicine to reality, to identify characteristics of tumors or patients where we can make a relatively dramatic impact using targeted agents," said Dr. Bruce Johnson of the Dana-Farber Cancer Institute and Harvard Medical School, in Boston.

read more | 1 comment | 3597 reads

Antivascular activity of lapatinib and bevacizumab in primary microcluster cultures of breast cancer and other human neoplasms
By gdpawel at 2008-09-12 04:09

Antivascular activity of lapatinib and bevacizumabtermterm in primary microcluster cultures of breast cancer and other human neoplasms

Sub-category: New Systemic Agents - New drugs and targets (includes anti-angiogenics) - Other

Category: Treatment

Meeting: 2008 Breast Cancer Symposium

Abstract No: 166

Author(s): L. Weisenthal, D. J. Lee, N. Patel



The following tyrosine kinase inhibitors (TKI) have been shown to have antivascular (AV) activity: sunitinibterm (Su), sorafenibterm (So), gefitinib (G), erlotinib (E), and imatinib (I). To date, AV activity has not been reported for lapatinib (LAP).

read more | 1 comment | 4386 reads

By gdpawel at 2008-08-16 21:53

HUNTINGTON BEACH, CA., August 11, 2008 -  The online edition of the Journal of Internal Medicine reports discovery of the first practical laboratory test to guide the use of new-generation drugs that kill cancer cells by cutting-off their blood supply.  The new test, called the Microvessel Vascular (MVV) assay, was developed by Larry Weisenthal, MD, PhD., a medical oncologist who operates a cancer testing laboratory in Huntington Beach, California.

The test works by measuring drug effects upon endothelial cells which make up blood vessels.  Its use could prolong lives, save money, and spare patients exposure to harmful side-effects of ineffective chemotherapyterm treatments.  The MVV test also could streamline development of new anti-cancer cancer drugs and identify effective and sometimes unexpected new drug combinations, such as one reported in the article.  Used today principally by cancer physicians, to choose effective therapies on a patient-by-patient basis, the MVV assay also has potential for use as an early-warning screen for a variety of illnesses ranging from heart disease, cancer, diabetes, autoimmune disorders, and many others.  Patents have been filed.

read more | 3479 reads

Catch of the day: zebrafish as a human cancer model
By Dross at 2008-07-31 22:50

Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects of different human cancers including lymphoblastic T-cell leukemiaterm, pancreatic cancer, melanoma and rhabdomyosarcoma. These models are already being utilized by academia and industry to search for genetic and chemical modifiers of cancer with success. The attention has been further stimulated by the amenability of zebrafish to pharmacological testing and the superior imaging properties of fish tissues that allow visualization of cancer progression and angiogenesis in live animals. This review summarizes the current zebrafish models of cancer and discusses their utility in human cancer research and future directions in the field

read more | 2274 reads

Cancer-resistant mouse could make BMT a fountain of youth
By Dross at 2007-11-28 21:09

LEXINGTON, Ky. (November 27, 2007) − A mouse resistant to cancer, even highly-aggressive types, has been created by researchers at the University of Kentucky. The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who found a tumor-suppressor gene called "Par-4" in the prostate.

The researchers discovered that the Par-4 gene kills cancer cells, but not normal cells. There are very few molecules that specifically fight against cancer cells, giving it a potentially therapeutic application.

read more | 1758 reads

Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
By Dross at 2007-08-03 22:49

In the past ten years, researchers in genome stability have observed that many kinds of cancer are associated with areas where human chromosomes break. They have hypothesized – but never proven – that slow or altered replication led to the chromosomes breaking.

In a Tufts University study published in the Aug. 3 journal "Molecular Cell," two molecular biologists have used yeast artificial chromosomes to prove the hypothesis. The Tufts researchers have found a highly flexible DNA sequence that increases fragility and stalls replication, which then causes the chromosome to break.

read more | 1 comment | 1483 reads

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