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brain cancer
The Three Rs Of Cancer Survival
By gdpawel at 2011-05-31 07:06
 

Solid tumours such as brain tumours are highly resistant to chemotherapyterm and radiation. One reason for this is a ‘reduce, reuse, recycle’ strategy that these tumours use to survive treatment. By developing a cancer drug that targets this recycling pathway, Malaghan Institute of Medical Research scientists have struck upon a novel approach for combating otherwise resistant and aggressive cancers.

read more | 19829 reads

Childhood brain tumor traced to normal stem cells gone bad
By Dross at 2008-08-12 20:26
 

BOSTON--An aggressive childhood brain tumor known as medulloblastoma originates in normal brain "stem" cells that turn malignant when acted on by a known mutant, cancer-causing oncogene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF).

Reporting in the Aug. 12 issue of Cancer Cell, the scientists say they have uncovered new origins for these tumors from early stem cells as well as more mature cells. Previously, scientists had assumed the tumors might only come from a single source: more mature cells which become neurons and do not have "stem" cell properties. The findings hint at potential new treatment approaches for medulloblastoma by targeting the origins of the tumors, and further suggest that not all patients' tumors may be born from the same cells.

read more | 2 comments | 1013 reads

Washington University Medical School News: Mouse model tightly matches pediatric tumor syndrome, will speed drug hunt -
By Dross at 2008-03-01 02:11
 

Frustrated by the slow pace of new drug development for a condition that causes pediatric brain tumors, a neurologist at Washington University School of Medicine in St. Louis decided to try to fine-tune the animal models used to test new drugs.

Instead of studying one mouse model of the disease causing the brain tumors, the laboratory of David Gutmann, M.D., Ph.D., the Donald O. Schnuck Family Professor of Neurology, evaluated three. They "auditioned" the three models to see which was the best match for neurofibromatosis 1, a genetic condition that increases the risk of brain tumors and afflicts more than 100,000 people in the United States.

read more | 1 comment | 1247 reads

Innovative Treatment Capitalizes on Unique Qualities of Short-Lived Radioisotope to Prolong Lives of Brain Tumor Patients
By Dross at 2008-01-31 21:15
 

Reston, Va.—In a study to determine safe dosages of the isotope astatine-211 for treating patients with recurring brain tumors, researchers were pleasantly surprised to find that not only was the isotope's potency sufficient to kill residual cancer cells without damaging sensitive healthy brain cells, but the patients experienced longer survival rates.

"Astatine-211 has as much as five times or more cell-killing efficiency than the standard treatments of external beam radiation or beta-particle injection," said Michael R. Zalutsky, professor of radiology and biomedical engineering at Duke University Medical Center in Durham, N.C. The ability to deliver such a potent cancer killer without causing neurotoxicity (damage to the delicate neurological system that controls brain function) would be a tremendous step forward in combating this lethal disease, he said.

read more | 1118 reads

Research suggests new treatment suitable for all patients
By Dross at 2008-01-01 14:58
 

WINSTON-SALEM, N.C. -- New research at Wake Forest University Baptist Medical Center suggests that a three-drug cocktail may one day improve outcomes in patients with glioblastoma multiforme (GBM), a type of brain tumor with a dismal prognosis. Two of the drug candidates have been developed, and the team is working on the third -- all targeted to kill or impair cancer cells and spare healthy brain.

Waldemar Debinski, M.D., Ph.D., senior researcher and director of the Wake Forest Brain Tumor Center of Excellence, predicts that the cocktail could be tested in patients within five years.

read more | 1 comment | 1128 reads

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