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What You Need To Know About Non-Hodgkin's Lymphoma
By Dross at 2007-03-05 05:41
What You Need To Know About Non-Hodgkin's Lymphoma

What Is Non-Hodgkin's Lymphomaterm?


Non-Hodgkin's lymphoma (also called NHL) is cancer that begins in the lymphatic system. To understand this disease, it is helpful to know about the lymphatic system.


The Lymphatic System


The lymphatic system is part of the body's immune system. The immune system fights infections and other diseases. In the lymphatic system, a network of lymph vessels carries clear fluid called lymph. Lymph vessels lead to small, round organs called lymph nodes. Lymph nodes are filled with lymphocytes (a type of white blood cell). The lymph nodes trap and remove bacteria or other harmful substances that may be in the lymph. Groups of lymph nodes are found in the neck, underarms, chest, abdomen, and groin. Other parts of the lymphatic system include the tonsils, spleen, and thymus. Lymphatic tissue is also found in other parts of the body including the stomach, skin, and small intestine. Lymphatic system. Lymphatic system. Non-Hodgkin's Lymphoma There are many types of non-Hodgkin's lymphoma. All types of lymphoma begin in cells of the lymphatic system. Normally, cells grow and divide to form new cells as the body needs them. When cells grow old, they die, and new cells take their place. Sometimes this process goes wrong. New cells form when the body does not need them, and old cells do not die when they should. These extra cells can form a mass of tissue called a growth or tumor. Non-Hodgkin's lymphoma begins when a lymphocyte (a B cell or T cell) becomes abnormal. Usually, non-Hodgkin's lymphoma starts in a B cell in a lymph node. The abnormal cell divides to make copies of itself. The new cells divide again and again, making more and more abnormal cells. The abnormal cells are cancer cells. They do not die when they should. They do not protect the body from infections or other diseases. Also, the cancer cells can spread to nearly any other part of the body.


Risk Factors


Doctors can seldom explain why one person develops non-Hodgkin's lymphoma and another does not. But research shows that certain risk factors increase the chance that a person will develop this disease. In general, the risk factors for non-Hodgkin's lymphoma include the following:

  • Weak immune system: Having a weak immune system (from an inherited condition, HIV infection, or certain drugs) increases the risk of developing non-Hodgkin's lymphoma.
  • Certain infections: Having certain types of infections increases the risk of developing lymphoma. However, lymphoma is not contagious. You cannot "catch" lymphoma from another person.

    The following are the main types of infection that can increase the risk of lymphoma:

  • Age: Although non-Hodgkin's lymphoma can occur in young people, the chance of developing this disease goes up with age. Most people with non-Hodgkin's lymphoma are older than 60. (For information about this disease in children, call the Cancer Information Service at 1-800-4-CANCER.)

Researchers are studying obesity and other possible risk factors for non-Hodgkin's lymphoma. People who work with herbicides or certain other chemicals may be at increased risk of this disease. Researchers are also looking at a possible link between using hair dyes before 1980 and non-Hodgkin's lymphoma.

Most people who have known risk factors do not get non-Hodgkin's lymphoma. On the other hand, people who do get the disease often have no known risk factors. If you think you may be at risk, you should discuss this concern with your doctor.




Non-Hodgkin's lymphoma can cause many symptoms:

  • Swollen, painless lymph nodes in the neck, armpits, or groin
  • Unexplained weight loss
  • Fever
  • Soaking night sweats
  • Coughing, trouble breathing, or chest pain
  • Weakness and tiredness that don't go away
  • Pain, swelling, or a feeling of fullness in the abdomen

Most often, these symptoms are not due to cancer. Infections or other health problems may also cause these symptoms. Anyone with symptoms that do not go away within 2 weeks should see a doctor so that problems can be diagnosed and treated.




If you have swollen lymph nodes or other symptoms that suggest non-Hodgkin's lymphoma, your doctor will help you find out whether they are from cancer or some other cause. Your doctor may ask about your personal and family medical history.

You may have some of the following exams and tests:

  • Physical exam: Your doctor checks for swollen lymph nodes in your neck, underarms, and groin. Your doctor also checks your spleen and liver to see if they are swollen.
  • Blood tests: The lab does a complete blood count to check the number of blood cells. The lab also checks for other substances, such as lactate dehydrogenase (LDH). Lymphoma may cause a high level of LDH.
  • Chest x-rays: You may have x-rays to check for swollen lymph nodes or other signs of disease in your chest.
  • Biopsy: Your doctor removes tissue to look for lymphoma cells. A biopsy is the only sure way to diagnose lymphoma. Your doctor may remove an entire lymph node (excisional biopsy) or only part of a lymph node (incisional biopsy). A pathologist checks the tissue for lymphoma cells with a microscope.

The doctor does not remove the tissue sample with a needle (needle biopsy). A needle cannot remove a large enough sample for the pathologist to diagnose lymphoma.

You may want to ask the doctor these questions before having a biopsy:

  • How will the biopsy be done?
  • Where will I have my biopsy?
  • How long will it take?
  • Will I be awake?
  • Will the biopsy hurt?
  • Are there any risks? What are the chances of infection or bleeding after the biopsy?
  • How long will it take me to recover?
  • How soon will I know the results? Who will explain them to me?
  • If I do have cancer, who will talk to me about the next steps? When?

Types of Lymphoma

When lymphoma is found, the pathologist will report the type. The most common types are diffuse large B-cell lymphoma and follicular lymphoma.

Lymphomas may be grouped by how quickly they are likely to grow:



Your doctor needs to know the extent (stage) of non-Hodgkin's lymphoma to plan the best treatment. Staging may involve some of these tests:

  • Bone marrow biopsy: The doctor uses a thick needle to remove a small sample of bone and bone marrow from your hipbone or another large bone. Local anesthesia can help control pain. A pathologist then looks for lymphoma cells in the sample.
  • CT scan: An x-ray machine linked to a computer takes a series of detailed pictures of your chest, abdomen, or pelvis. You may receive an injection of contrast material. Also, you may be asked to drink another type of contrast material. The contrast material makes it easier for the doctor to see swollen lymph nodes and other abnormal areas on the x-ray.
  • MRI: A powerful magnet linked to a computer is used to make detailed pictures of your spinal cord, bone marrow, or brain. Your doctor can view these pictures on a monitor and can print them on film.
  • Ultrasound: An ultrasound device sends out sound waves that people cannot hear. The small hand-held device is held against your body. The waves bounce off nearby tissues, and a computer uses the echoes to create a picture. Tumors may produce echoes that are different from the echoes made by healthy tissues. The picture can show possible tumors.
  • Spinal tap: The doctor uses a long, thin needle to remove fluid from the spinal column. Local anesthesia can help control pain. You must lie flat for a few hours afterward so that you will not get a headache. The lab checks the fluid for lymphoma cells or other problems.
  • PET scan: You receive an injection of a small amount of radioactive sugar. A machine makes computerized pictures of the sugar being used by cells in the body. Cancer cells sometimes show up in the pictures as areas of high activity.

The stage is based on where lymphoma cells are found (in the lymph nodes or in other organs or tissues). The stage also depends on how many areas are affected. The stages of non-Hodgkin's lymphoma are as follows:

  • Stage I: The lymphoma cells are in a single lymph node group (such as in the neck or underarm). Or, if the abnormal cells are not in the lymph nodes, they are in only one part of a tissue or organ (such as the lung, but not the liver or bone marrow).
  • Stage II: The lymphoma cells are in at least two lymph node groups on the same side of (either above or below) the diaphragm. Or, the lymphoma cells are in an organ and the lymph nodes near that organ (on the same side of the diaphragm). There may be lymphoma cells in other lymph node groups on the same side of the diaphragm.
  • Stage III: The lymphoma is in groups of lymph nodes above and below the diaphragm. It also may be found in an organ or tissue near these lymph node groups.
  • Stage IV: The lymphoma is throughout at least one organ or tissue (in addition to the lymph nodes). Or, it is in the liver, blood, or bone marrow.




Many people with non-Hodgkin's lymphoma want to take an active part in making decisions about their medical care. It is natural to want to learn all you can about your disease and your treatment choices. However, shock and stress after the diagnosis can make it hard to think of everything you want to ask the doctor. It often helps to make a list of questions before you visit your doctor.

To help remember what your doctor says, you may take notes or ask whether you may use a tape recorder. You may also want to have a family member or friend with you when you talk to your doctor - to take part in the discussion, to take notes, or just to listen.

You do not need to ask all your questions at once. You will have other chances to ask your doctor to explain things that are not clear and to ask for more information.

Your doctor may refer you to a specialist, or you may ask for a referral. Specialists who treat non-Hodgkin's lymphoma include hematologists, medical oncologists, and radiation oncologists. Your doctor may suggest that you choose an oncologist who specializes in the treatment of lymphoma. Often, such doctors are associated with major academic centers.

Getting a Second Opinion

Before starting treatment, you might want a second opinion about your diagnosis and your treatment plan.

It is a good idea to get a second opinion about the type of lymphoma that you have. The treatment plan varies by the type of lymphoma. A pathologist at a major referral center can review your biopsy.

You also may want a second opinion about your treatment plan. Many insurance companies cover a second opinion if you or your doctor requests it. It may take some time and effort to gather your medical records and arrange to see another doctor. Most of the time, it is not a problem to take several weeks to get a second opinion. The delay in starting treatment usually will not make treatment less effective. To be sure, you should discuss this delay with your doctor. Some people with non-Hodgkin's lymphoma need treatment right away.

There are a number of ways to find a doctor for a second opinion:

  • Your doctor may refer you to one or more lymphoma specialists. At cancer centers, many specialists often work together as a team.
  • The NCI's Cancer Information Service, at 1-800-4-CANCER, can tell you about nearby treatment centers. Information Specialists also can help you online through LiveHelp at
  • A local or state medical society, a nearby hospital, or a medical school can usually provide the names of specialists in your area.
  • The American Board of Medical Specialties (ABMS) has a list of doctors who have had training and passed exams in their specialty. You can find this list in the Official ABMS Directory of Board Certified Medical Specialists. This Directory is in most public libraries. Or you can look up doctors at (Click on "Who's Certified.")
  • The NCI provides a helpful fact sheet called "How To Find a Doctor or Treatment Facility If You Have Cancer."
  • Nonprofit groups with an interest in lymphoma may be of help. Many such groups are listed in the NCI fact sheet "National Organizations That Offer Services to People With Cancer and Their Families."

Preparing for Treatment

The choice of treatment depends on many factors, including:

  • Which type of non-Hodgkin's lymphoma you have (for example, follicular lymphoma)
  • The stage of your cancer (where the lymphoma is found)
  • How quickly the cancer is growing (whether it is indolent or aggressive lymphoma)
  • Your age
  • Whether you have other health problems

Your doctor can describe your treatment choices and their expected results. You and your doctor can work together to develop a treatment plan that meets your needs.

You may want to ask the doctor these questions before treatment begins:

  • What is the stage of my cancer? Where are the tumors?
  • What are my treatment choices? Which do you recommend for me?
  • What are the expected benefits of each kind of treatment? How will we know the treatment is working? What tests will be used to check its effectiveness? How often will I get these tests?
  • What are the risks and possible side effects of each treatment? What can we do to control my side effectsterm?
  • How long will treatment last?
  • Will I have to stay in the hospital?
  • How will treatment affect my normal activities?
  • What can I do to take care of myself during treatment?
  • What is the treatment likely to cost? Will my insurance cover this treatment?
  • How often will I need checkups?
  • Would a clinical trial (research study) be appropriate for me?

Treatment Methods

If you have indolent non-Hodgkin's lymphoma without symptoms, you may not need treatment for the cancer right away. The doctor watches your health closely so that treatment can start when you begin to have symptoms. Not getting cancer treatment right away is called watchful waiting.

If you have indolent lymphoma with symptoms, you will probably receive chemotherapy and biological therapy. Radiation therapy may be used for patients with Stage I or Stage II lymphoma.

If you have aggressive lymphoma, the treatment is usually chemotherapyterm and biological therapy. Radiation therapy also may be used.

If non-Hodgkin's lymphoma comes back after treatment, doctors call this a relapse or recurrence. People whose lymphoma comes back after treatment may receive stem cell transplantation.

Because cancer treatments often harm healthy cells and tissues, side effects are common. Side effects depend mainly on the type and extent of the treatment. Side effects may not be the same for each person, and they may change from one treatment session to the next. The younger a person is, the easier it may be to cope with treatment and its side effects.

Before treatment starts, the health care team will explain possible side effects and suggest ways to help you manage them. The NCI provides booklets about cancer treatments and coping with side effects. These booklets include Radiation Therapy and You, Chemotherapy and You, Biological Therapy, and Eating Hints for Cancer Patients.

At any stage of the disease, you can have treatments to control pain and other symptoms, to relieve the side effects of therapy, and to ease emotional and practical problems. This kind of treatment is called supportive care. (See the "Supportive Care" section.)

You may want to talk to your doctor about taking part in a clinical trial, a research study of new treatment methods. "The Promise of Cancer Research" section explains clinical trials.

Watchful Waiting

People who choose watchful waiting put off having cancer treatment until they have symptoms. Doctors sometimes suggest watchful waiting for a patient with indolent lymphoma. A person with indolent lymphoma may not have problems that require cancer treatment for a long time. Sometimes the tumor may even shrink for a while without therapy. By putting off treatment, a patient can avoid the side effects of chemotherapy or radiation therapy.

If you and your doctor agree that watchful waiting is a good idea, the doctor will check you regularly (every 3 months). You will receive treatment if symptoms occur or get worse.

Some people do not choose watchful waiting because they don't want to worry about having cancer that is not treated. Those who choose watchful waiting but later become worried should discuss their feelings with the doctor.

You may want to ask the doctor these questions before choosing watchful waiting:

  • If I choose watchful waiting, can I change my mind later on?
  • Will the disease be harder to treat later?
  • How often will I have checkups?
  • Between checkups, what problems should I report?


Chemotherapy uses drugs to kill cancer cells. It is called systemic therapy because the drugs travel through the bloodstream. The drugs can reach cancer cells in almost all parts of the body.

You may receive chemotherapy by mouth, through a vein, or in the space around the spinal cord. Treatment is usually in an outpatient part of the hospital, at the doctor's office, or at home. Some patients need to stay in the hospital during treatment.

If a patient has lymphoma in the stomach caused by H. pylori infection, the doctor may treat this lymphoma with antibiotics. After the drug cures the infection, the cancer also may go away.

The side effects of chemotherapy depend mainly on the specific drugs and the dose. The drugs affect cancer cells and other cells that divide rapidly:

  • Blood cells: When drugs affect your healthy blood cells, you are more likely to get infections, bruise or bleed easily, and feel very weak and tired.
  • Cells in hair roots: Chemotherapy can cause you to lose your hair. Your hair will grow back, but sometimes the new hair is somewhat different in color and texture.
  • Cells that line the mouth, stomach, and other parts of the digestive tract: Chemotherapy can cause poor appetite, nausea and vomiting, diarrhea, trouble swallowing, or mouth and lip sores.

The drugs used for non-Hodgkin's lymphoma also may cause skin rashes or blisters, and headaches or other aches. Your skin may become darker. Your nails may develop ridges or dark bands.

Your doctor can suggest ways to control many of these side effects.

You may want to ask the doctor these questions before starting chemotherapy:

  • Which drug or drugs will I have?
  • How do the drugs work?
  • What are the expected benefits of the treatment?
  • What are the risks and possible side effects of treatment? What can we do about them?
  • Are there any long-term effects from the drugs?
  • When will treatment start? When will it end?
  • How will treatment affect my normal activities?

Biological Therapy

People with certain types of non-Hodgkin's lymphoma may have biological therapy. This type of treatment helps the immune system fight cancer.

Monoclonal antibodies are the type of biological therapy used for lymphoma. They are proteins made in the lab that can bind to cancer cells. They help the immune system kill lymphoma cells. Patients receive this treatment through a vein at the doctor's office, clinic, or hospital.

Flu-like symptoms such as fever, chills, headache, weakness, and nausea may occur. Most side effects are easy to treat. Rarely, a patient may have more serious side effects, such as breathing problems, low blood pressure, or severe skin rashes. Your doctor or nurse can tell you about the side effects that you can expect and how to manage them.

You may want to ask the doctor these questions before having biological therapy:
  • What will the treatment do?
  • Will I have to stay in the hospital?
  • How will we know if the treatment is working?
  • How long will I be on biological therapy?
  • Will I have side effects during treatment? How long will they last? What can we do about them?

Radiation Therapy

Radiation therapy (also called radiotherapy) uses high-energy rays to kill non-Hodgkin's lymphoma cells. It can shrink tumors and help control pain.

Two types of radiation therapy are used for people with lymphoma:

  • External radiation: A large machine aims the rays at the part of the body where lymphoma cells have collected. This is local therapy because it affects cells in the treated area only. Most people go to a hospital or clinic for treatment 5 days a week for several weeks.
  • Systemic radiation: Some people with lymphoma receive an injection of radioactive material that travels throughout the body. The radioactive material is bound to antibodies that seek out lymphoma cells. The radiation destroys the lymphoma cells.

The side effects of radiation therapy depend mainly on the type of radiation therapy, the dose of radiation, and the part of the body that is treated. For example, external radiation to your abdomen can cause nausea, vomiting, and diarrhea. Radiation to the lung can cause coughing or shortness of breath. In addition, your skin in the treated area may become red, dry, and tender. You also may lose your hair in the treated area.

You are likely to become very tired during external radiation therapy, especially in the later weeks of treatment. Resting is important, but doctors usually advise patients to try to stay as active as they can.

People who get systemic radiation also may feel very tired. They may be more likely to get infections.

If you have radiation therapy and chemotherapy at the same time, your side effects may be worse. The side effects can be distressing. You can talk with your doctor about ways to relieve them.

You may want to ask the doctor these questions before starting radiation therapy:

  • Why do I need this treatment?
  • What are the expected benefits of radiation therapy?
  • What are the risks and side effects of this treatment? What can we do about them?
  • Are there any long-term effects?
  • When will the treatments begin? When will they end?
  • How will I feel during therapy?
  • How will treatment affect my normal activities?

Stem Cell Transplantation

A person with lymphoma who has relapsed may receive stem cell transplantation. A transplant of blood-forming stem cells allows a person to receive high doses of chemotherapy, radiation therapy, or both. The high doses destroy both lymphoma cells and healthy blood cells in the bone marrow. Later, the patient receives healthy blood-forming stem cells through a flexible tube placed in a large vein in the neck or chest area. New blood cells develop from the transplanted stem cells.

Stem cell transplants take place in the hospital. The stem cells may come from the patient or from a donor:

  • Autologous stem cell transplantation: This type of transplant uses the patient's own stem cells. The stem cells are removed from the patient, and the cells may be treated to kill lymphoma cells that may be present. The stem cells are frozen and stored. After the patient receives high-dose treatment, the stored stem cells are thawed and returned to the patient.
  • Allogeneic stem cell transplantation: Sometimes healthy stem cells from a donor are available. The patient's brother, sister, or parent may be the donor. Or the stem cells may come from an unrelated donor. Doctors use blood tests to be sure the donor's cells match the patient's cells.
  • Syngeneic stem cell transplantation: This type of transplant uses stem cells from the patient's healthy identical twin.

You may want to ask the doctor these questions before having a stem cell transplant:

  • What are the possible benefits and risks of different types of transplants?
  • What kind of stem cell transplant will I have? If I need a donor, how will we find one?
  • How long will I need to be in the hospital? Will I need special care?
  • How will we know if the treatment is working?
  • What can we do about side effects?
  • How will treatment affect my normal activities?
  • What is my chance of a full recovery?

Supportive Care


Non-Hodgkin's lymphoma and its treatment can lead to other health problems. You may receive supportive care to prevent or control these problems and to improve your comfort and quality of life during treatment.

You may receive antibiotics and other drugs to help protect you from infections. Your health care team may advise you to stay away from crowds and from people with colds and other contagious diseases. If an infection develops, it can be serious, and you will need treatment right away.

Non-Hodgkin's lymphoma and its treatment also can lead to anemia, which may make you feel very tired. Drugs or blood transfusions can help with this problem.


Complementary and Alternative Medicine


Some people with cancer use complementary and alternative medicine (CAM):

  • An approach is generally called complementary medicine when it is used along with standard treatment.
  • An approach is called alternative medicine when it is used instead of standard treatment.

Acupuncture, massage therapy, herbal products, vitamins or special diets, visualization, meditation, and spiritual healing are types of CAM. Some people report that such approaches help them feel better.

However, some types of CAM can create health problems. An alternative medicine may not work as well as standard treatment. Patients with aggressive lymphoma who use alternative medicine instead of standard treatment may reduce the chance to control or cure their disease.

It is important to keep in mind that some complementary medicines may interfere with standard treatment. Combining CAM with standard treatment may even be harmful. Before trying any type of CAM, you should discuss its possible benefits and risks with your doctor.

Some types of CAM are expensive. Health insurance may not cover the cost.

The NCI offers a fact sheet called "Complementary and Alternative Medicine in Cancer Treatment: Questions and Answers."

You may want to ask the doctor these questions before you choose CAM:

  • What benefits can I expect from this therapy?
  • What are its risks?
  • Do the expected benefits outweigh the risks?
  • What side effects should I watch for?
  • Will the therapy change the way my cancer treatment works? Could this be harmful?
  • Is this therapy under study in a clinical trial? If so, who sponsors the trial?
  • Will my health insurance pay for this therapy?



It is important for you to eat well. Eating well means getting enough calories to maintain a good weight and enough protein to keep up your strength. Good nutrition may help people with cancer feel better and have more energy.

But eating well can be hard. You may not feel like eating if you are tired or in pain. Also, the side effects of treatment (such as nausea, vomiting, or mouth sores) can be a problem. Some people find that foods do not taste as good during cancer treatment.

The doctor, dietitian, or other health care provider can suggest ways to maintain a healthy diet. 



3 comments | 26267 reads

by gdpawel on Fri, 2013-05-03 21:48
Jessica Lewis, PA

In some instances, patients may be started on medicines to prevent or minimize infection. Infection in patients with impaired immune system function (due to lymphoma or treatment of lymphoma) can be life threatening. Ultimately, your doctor will determine whether to start such medications, but some current literature helps medical providers make this decision.

The National Comprehensive Cancer Network and American Society of Clinical Oncology provide summaries of factors that predict a lymphoma patient’s risk of developing fever and infection. These factors include age, performance status, type of cancer, status of disease (remission vs. active disease), type of treatment, the presence of a low infection-fighting white blood cell count (neutropenic), and prior episodes of fever with chemotherapy treatment. Patients with lymphoma are generally classified as having intermediate risk, although some patients with CLL or T-cell lymphoma may be considered high risk.

Prevention of bacterial infections: Common prophylactic medications include levofloxacin or ciprofloxacin. Prophylaxis is recommended for intermediate or high-risk patients, including patients that are expected to have neutropenia. There have been few randomized-controlled trials that have investigated the use of antibiotics to prevent development of fever and infection in lymphoma patients that are receiving chemotherapy. The largest randomized-controlled study, by Cullen et al in 2005, included 1,565 patients with solid cancers and lymphomas treated with chemotherapy that would lower the white blood cell count. In this study, patients were randomly assigned a placebo or levofloxacin. The authors found a decrease in the incidence of fever and decreased rates of probable infection and hospitalization. However, patients who received levofloxacin did not have a statistically significant decreased rate of severe infection (including lethal infections). As per 2012 NCCN and ASCO guidelines, the use of levofloxacin prophylaxis is only recommended for patients with neutropenia that lasts longer than 7 days.

Prevention of fungal infections: Medications to prevent fungal infections are not usually needed in lymphoma patients. ASCO guidelines recommend considering prophylaxis only for patients with profoundly low white blood cell counts (ANC <100) longer than 7 days. Additionally, patients should limit exposure to construction or demolition sites, and quit cigarette smoking to reduce risk of fungal infections.

Prevention of viral infections: Antiviral medications may be recommended. If you have been exposed to hepatitis B infection, you may be started on medication to prevent this from becoming an active infection. If you had the chicken pox as a child you are at risk of developing shingles, and you may benefit from preventative medication. Patients with lymphoma should not receive the shingles vaccine.

PCP prevention: Some patients are at risk of developing pneumonia, caused by Pneumocytus jirovecii (also referred to as PCP). You may require preventative medication, typically with TMP-SMX, if you are on steroids for a prolonged period of time (>1 month), or are receiving treatment with alemtuzumab or purine analogs (i.e., fludarabine).

Other preventative measures: ASCO 2012 guidelines recommended all patients who are receiving cancer treatment to receive the seasonal flu vaccine, along with their family and household contacts. Guidelines from the Centers for Disease Control (CDC) include administration of a pneumococcal vaccine in all patients with lymphoma.

The Lymphoma Program at New York-Presbyterian Hospital/Weill Cornell Medical Center

by gdpawel on Fri, 2013-06-28 22:22
Michael Grossbard, M.D.
Lymphoma Program
Continuum Cancer Centers
New York

There are many different subtypes of lymphoma and these subtypes have different ways in which they manifest themselves in patients. One major way to distinguish lymphomas is to assess whether they are of T-cell or B-cell origin (T and B representing different types of lymphocytes in the body). These subtypes can be distinguished by staining lymphoma cells to determine whether they have T-cell or B-cell antigens on their surface.

Another way to distinguish lymphomas is to examine tumor cells under the microscope and assess their size and shape. For example, some aggressive lymphomas have very large malignant cells (and are known as large cell lymphomas). A third way to evaluate lymphoma subtypes is to assess genetic changes within the tumor cell by using molecular biologic techniques or examining the chromosomes directly (cytogenetic analysis).

By determining the subtype of lymphoma, specific therapy programs can be offered that will optimize the chance for a favorable response. The standard therapy for a diffuse large B-cell lymphoma is different from that of a Burkitt’s lymphoma or a follicular lymphoma. Likewise, these different entities have different prognoses.

What is the role of cytogenetic analysis?

Although cytogenetic testing is often impossible because many patients have dry bone marrow taps, all of the faculty members generally recommend sending adequate specimens for analysis to both assist in diagnosis, especially in excluding other conditions, and to assess prognosis in younger patients being considered for an allotransplant. In addition, most investigators believe the results can affect clinical decision-making, potentially swaying them to employ, for example, an immunomodulatory agent in patients when a 5q deletion has been detected. Significantly, unlike multiple myeloma, where there is no easy standard to consider, cytogenetics in MF from a practical perspective revolve around the factors identified in the Dynamic International Prognostic Scoring System (DIPSS) Plus, giving oncologists a road map of what should be looked at in this regard. - Research To Practice

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