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How T lymphocytes attack
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Our immune system finds it difficult to eliminate tumours effectively. Deciphering the strategies it implements may increase the immune system's effect on tumour cells and thus improve the clinical perspectives for anticancer immune therapy. At the Institut Curie, INSERM and CNRS researchers have used two-photon microscopy to demonstrate, for the first time in vivo and real-time, how T lymphocytes infiltrate a solid tumour in order to fight it. These "defenders" methodically encircle the enemy positions and "patrol" until they meet a tumour cell, which they have previously learnt to recognise. They then halt to eliminate it, before resuming their rounds. The rapidity of the advance achieved by T lymphocytes is indicative of either the absence of an adversary, or defeat of the immune system in the battlefield. This scenario was published in The Journal of Experimental Medicine.
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How T lymphocytes attack
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