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Prevention of Chemotherapy-Induced Mucositis
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By HCat at 2007-01-12 06:22
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Prevention of Chemotherapy-Induced Mucositis
   Mucositisterm from chemotherapyterm can be prevented with cryotherapyterm or chlohexadine rinses. Mucositis is an inflammation (and dying) of the cells that line the mouth, throat, and the rest of the digestive tract. It is a common side effect seen in chemotherapy and radiation treatment but seems to be under reported in statistics. Its symptoms can include ulcers and raw sores in the mouth as well as loss of taste and difficulty eating. A supportive care abstract from the Annals of Oncology recently reported findings at the 31st Congress of the European Society for Medical Oncology (ESMO) (abstract 988 O).
   The findings showed that cryotherapy or chlorhexidineterm mouth rinses was effective at preventing mucositis in patients receiving oral doses of 5-FUterm (5 fluorouraciltermterm). 13% of chlorhexidine, 11% cryotherapy, and 33% saline (placebo control) experienced mucositis after treatment. Chlorhexidine (sometimes chlorhexadinetermterm) is a common ingredient in mouthwash as it is an antimicrobial agent. The chlorhexidine treatment was 0.1% 15mL mouth rinse for 1 minute, 3 times daily for 3 weeks. The cryotherapy was crushed ice in a rinse 10 minutes before to 35 minutes after chemotherapy. The abstract has been uploaded.
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