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Myeloablative intensified conditioning regimen with in vivo T-cell depletion (ATG)
By Anonymous at 2006-12-01 02:08
Myeloablative intensified conditioning regimen with in vivo T-cell depletion (ATG)

We investigated toxicity and efficacy of in vivo T-cell depletion with anti-thymocyte globulin (ATG) as part of an intensified myeloablative conditioning regimen followed by allogeneic stem cell transplantation in patients with advanced multiple myeloma. The conditioning regimen consisted of modified total body irradiation, busulfan and cyclophosphamide (n=15) or in the case of prior dose-limiting radiotherapy of busulfan and cyclophosphamide (n=3). The median age was 44 years (range, 29-53) and the median time from diagnosis to transplant was 12 months (range, 6-144). Grade II-IV acute graft-versus-host disease (GvHD) occurred in six patients (35%). Severe grade III/IV GvHD developed in one patient (6%). Three patients died of therapy-related causes (17%). A complete remission (CR) with negative immunofixation after allogeneic transplantation was seen in eight of the evaluable patients (53%). After a median follow-up of 41 months (range, 8-84), the estimated overall survival at 6 years for all patients is 77% (CI 95%: 58-96%). The estimated progression-free survival at 6 years for all patients is 31% (CI 95%: 2-59%) and 46% (CI 95%: 9-83%) for patients with CR. In vivo T-cell depletion with ATG resulted in a low rate of severe GvHD with low treatment-related mortality, and a substantial number of long-term survivors. enter the thread for publication



1 comment | 2057 reads

by admin on Fri, 2006-12-01 02:13
Attached you have the original journal paper detailing t cell depletion in myeloblative transplants. Some centers are doing similar work with nonmyeloablative.

translation? The person receiving this treatment woulg get 2700 grey's of radiation, enough to completely destroy their marrow, as opposed to other newer protocols wherein the patient would receive 200 or 0 grey's.

The T cell depletion causes less graft vs host disease but also is less effective towards the myeloma

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