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Callisto Pharmaceuticals Starts Phase I Clinical Trial with L-Annamycin in Pediatric Relapsed and Refractory Acute Leukemia
By HCat at 2007-03-11 23:27
Callisto Pharmaceuticals Starts Phase I Clinical Trial with L-Annamycin in Pediatric Relapsed and Refractory Acute Leukemia

    Callisto Pharmaceuticals, Inc. opened a phase I clinical trial testing L-Annamycin in children and young adults on February 22nd and announced dosing on March 8th. The trial will test the drug in pediatric patiens with refractory or relapsed acute lymphocytic leukemiaterm (ALL) or acute myelogenous leukemia (AML). Patients with relapsed or refractory acute leukemia who have prior treatment with approved chemotherapeutics generally have a poor prognosis at this point in the disease and are in need of new agents.

    POETIC (Pediatric Oncology Experimental Therapeutics Investigators Consortium) is participating in the trial which includes Phoenix Children's, Children's Healthcare of Atlanta, Johns Hopkins Kimmel Cancer Center, MD Anderson Cancer Center, Memorial Sloan-Kettering Cancer Center, University of Florida Health Science Center, The Children's Hospital - Denver CO, University of Arizona, University of Calgary, University of Florida and Vanderbilt Medical Center.

    L-Annamycin has been shown in another phase I clinical trial as well as in animal studies to circumvent multi-drug resistance with a decreased cardiotoxicity. In 2005, L-Annamycin was given orphan drug designation to treat both ALL and AML.

Here is the press release for dosing of L-Annamycin in phase I clinical trial from Callisto Pharmaceuticals.



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