Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring.
Authors:
Lieb, W.;
Pencina, M.J.;
Wang, T.J.;
Larson, M.G.;
Lanier, K.J.;
Benjamin, E.J.;
Levy, D.;
Tofler, G.H.;
Meigs, J.B.;
Newton-Cheh, C.;
Vasan, R.S.;
,Source:
Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring., Hypertension, Volume 52, Issue 2, United States (2008)
ISBN:
1524-4563
Call Number:
18574071
Accession Number:
18574071
URL:
http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18574071&retmode=ref&cmd=prlinks
Keywords:
Adult;
Adult Children;
Aged;
Albumins;
Biological Markers;
Blood Pressure;
C-Reactive Protein;
Case-Control Studies;
Creatinine;
Female;
Genetic Predisposition to Disease;
Genomic Imprinting;
Humans;
Hypertension;
Incidence;
Male;
Middle Aged;
Reference Values;
Renin;
Risk
Abstract:
Children of parents with hypertension are at increased risk of developing high blood pressure. We hypothesize that circulating concentrations of putative biomarkers (that may play a role in development of high blood pressure) are higher in nonhypertensive offspring of parents with hypertension. We compared concentrations of 4 different biomarkers (urinary albumin:creatinine ratio, circulating C-reactive protein, aldosterone:renin ratio, and plasminogen activator inhibitor-1) in nonhypertensive Framingham offspring study participants with none (n=233), 1 (n=474), or both (n=322) parents with hypertension. Parental hypertension was defined as onset before age 60 years, based on longitudinal observations of the original Framingham cohort. Serum C-reactive protein concentrations were higher in nonhypertensive offspring with 1 (median: 1.7; Q1 to Q3: 0.8 to 3.6 mg/L) or both parents with hypertension (median: 1.8; Q1 to Q3: 0.7 to 3.6 mg/L) compared with offspring without parental hypertension (median: 1.4; Q1 to Q3: 0.7 to 3.2 mg/L). In multivariable analyses, parental hypertension was associated with higher serum C-reactive protein concentration in offspring (15% increase per parent with hypertension; P=0.004). Prospectively, the relation of parental hypertension to longitudinal changes in blood pressure in the nonhypertensive offspring was attenuated on adjustment for C-reactive protein (P=0.04 for attenuation). The levels of the other biomarkers evaluated did not significantly differ in offspring according to parental hypertension status. In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk.
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