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TAX 324 Phase III Study Shows Docetaxel Increases Survival in Head, Neck Cancer
By HCat at 2007-02-14 02:20
TAX 324 Phase III Study Shows Docetaxel Increases Survival in Head, Neck Cancer


    Marshall R. Posner, MD, medical director of the Head and Neck Oncology Program at the Dana-Farber Cancer Institute in Boston reported at the 2006 annual meeting of the American Society of Clinical Oncology (ASCO) on the randomized Phase III TAX 324 Study Group. 501 patients with locally advanced squamous cell carcinomaterm of the head and neck (SCCHN) (oral cavity, oropharynx, larynx and hypopharynx) were the focus of the study.

 

    In the study, patients receiving docetaxel in combination with cisplatin and 5-FUterm as induction (neoadjuvant) therapy, followed by chemoradiotherapy and surgery were compared to those not receiving docetaxel. The results showed an impressive 70.6 months median overall survival in patients who took docetaxel compared to 30.1 months for those not receiving docetaxel in their treatment. There was a 30% reduction in mortality rate for those patients receiving docetaxel. There was an absolute three-year survival improvement of 14% in the docetaxel group as well. Progression-free survival (PFS) was also significantly greater with the docetaxel regimen with two-year PFS at 53% compared to 42%.

 

    Grade 3/4 neutropenia occurred in 85% of the docetaxel group and 56% in the non-docetaxel group. However, there was no other significant increase in toxicity, and other trials are continuing in conjunction with other targeted molecular agents for treatment of SCCHN.

 

A link to the ASCO meeting presentation and abstract can be found here.



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